Met ID in non-clinical species early on can be performed to confirm or retract potential discrepancies between species in vitro. The plasma metabolite profile (circulating metabolites) many times reflect the metabolic pathways in vivo to a larger extent than in vitro data despite the fact that not all metabolites formed and excreted are present at all or at detectable levels in plasma.
We perform in vivo Met ID studies as part of MIST evaluation but also exploratory and as problem solving activities. We handle blood, plasma, urine, feces, bile, tissues and other body fluids (e.g. saliva, humour).